Sansone Anna

Office telephone : 
+39 051 639 8297
Isof 12
Office number: 
8 297
Research Unit: 

She graduated in Pharmacy in 2004 ( Sapienza University in Rome), and she got the Ph.D in Pharmaceutical Science, Medicinal Chemistry field, in 2008 (Sapienza University in Rome) defending her thesis focused on design, development, synthesis, characterization and biological evaluation of peptides and pseudopeptides as inhibitors of ß -Amiloyd in Alzheimer, as endomorphin analogues and chemotactic agents.
From 2008 to March 2011 she obtained different collaboration grants conferred by: CNR Crystallographic Institute for the development of Nucleic Acid molecules, by Cency Bolognetti Foundation for the development of antiviral activity peptides and by Chemical Science Department in Padova University for peptide nanoenzymes inibithor synthesis.
In 2011 she obtained a permanent researcher position in ISOF-CNR joining the BIO-FREE RADICALS reasearch group becaming coworker of Dr Chryssostomos Chatgilialoglu and Dr Carla Ferreri;she is lab tutor for post-doc and Ph.D students and supervisor for master students and students of erasmus projects; her skills are focused on: radical mechanism damage of lipids and proteins from chemical aspect to life science involvement, development of analytical methodologies for lipidomic application, design and development of proteo-liposomes for drug radical mechanism discovery and antioxidant activities, synthesis, characterization and evaluation of bioactive molecules.


"Wine lees modulate lipid metabolism and induce fatty acid remodelling in zebrafish".M. Caro, A. Sansone, J. Amezaga, V. Navarro, C. Ferreri and I. Tueros*.Food Funct. 2017 Mar 21. doi: 10.1039/c6fo01754a.

"Fatty acids in membranes as homeostatic, metabolic and nutritional biomarkers: recent advancements in analytics and diagnostics" Carla Ferreri *, Annalisa Masi, Anna Sansone, Giorgia Giacometti, Anna Vita Larocca, Gewrgia Menounou, Roberta Scanferlato, Silvia Tortorella, Domenico Rota, Marco Conti, Simone Deplano, Maria Louka, Anna Rosaria,Maranini, Arianna Salati, Valentina Sunda, Chryssostomos Chatgilialoglu.DIAGNOSTICS /special Issue:Biomarker in blood 2016.doi:10.3390/diagnostics7010001. 22 December 2016

"Fatty acid-related modulations of membranes fluidity in cells: detection and implications".G. Maulucci, O. Cohen, B. Daniel, A Sansone, P.I. Petropoulou, S. Filou, A.Spyridonidis, G. Pani, M. De Spirito, C. Chatgilialoglu, C. Ferreri, K.E. Kypreos & S. Sasson. Free Radical Research.DOI 10.1080/10715762.2016.1231403.Published online: 05 Sep 2016.

"Hexadecenoic fatty acid isomers in human blood lipids and their relevance for the interpretation of lipidomic profiles"
Anna Sansone,Evanthia Tolika,Maria Louka,Valentina Sunda,Simone Deplano,Michele Melchiorre,Dimitri Anagnostopoulos,Chryssostomos Chatgilialoglu,Cesare Formisano,Rosa Di Micco,Maria Rosaria Faraone Mennella, Carla Ferreri, PLOS ONE | DOI:10.1371/journal.pone.0152378 April 5, 2016

"Building up spectral libraries for mapping erythrocyte membrane by hyperspectral dark field microscopy".
Marco Conti, Roberta Scanferlato, Maria Louka, Anna Sansone, Carla Marzetti,and Carla Ferreri.
Biomedical Spectroscopy and Imaging 5 (2016) 175–184

Effects of bleomycin and antioxidants on the fatty acid profile of testicular cancer cell membranes
A. Cort T. Ozben, M. Melchiorre, C. Chatgilialoglu, C. Ferreri, A. Sansone. BBA - Biomembranes
Biochim Biophys Acta. 2016 Feb;1858(2):434-41. doi: 10.1016/j.bbamem.2015.12.005. Epub 2015 Dec 4.,

"The molecular mechanism behind reactive aldehyde action on transmembrane translocations of proton and potassium ions.;Jovanovic O, Pashkovskaya AA, Annibal A, Vazdar M, Burchardt N, Sansone A, Gille L, Fedorova M, Ferreri C, Pohl EE.
Free Radic Biol Med. 2015 Oct 28. pii: S0891-5849(15)01093-X. doi: 10.1016/

"Bleomycin-induced trans lipid formation in cell membranes and in liposome models"
Aysegul Cort, Tomris Ozben, Anna Sansone, Sebastian Barata-Vallejo, Chryssostomos
Chatgilialoglud and Carla Ferreri*.Organic &BiomolecularChemistry.Accepted, Nov 2014.

"Problem solving approach for the diastereoselective synthesis of (5'S)- and (5'R)-5',8 cyclopurine lesions.” Chryssostomos Chatgilialoglu, Carla Ferreri, Annalisa Masi, Anna Sansone, Michael A. Terzidis and Michail Tsakos. Org. Chem. Front, DOI: 10.1039/C4QO00133H, 2014;

"Lipid geometrical isomerism: from chemistry to biology and diagnostics". Chatgilialoglu C, Ferreri C, Melchiorre M, Sansone A, Torreggiani A.Chem Rev. 2014 Jan 8;114(1):255-84. doi: 10.1021/cr4002287. Epub 2013 Sep 19.

"Hexadecenoic fatty acid isomers: a chemical biology approach for human plasma biomarker development".
Sansone A, Melchiorre M, Chatgilialoglu C, Ferreri C.Chem Res Toxicol. 2013 Oct 2.

"Free radicals in chemical biology: from chemical behavior to biomarker development".Chatgilialoglu C, Ferreri C, Masi A, Melchiorre M, Sansone A, Terzidis MA, Torreggiani A.J Vis Exp. 2013 Apr 15;(74). doi: 10.3791/50379.

"Biomimetic Models of Radical Stress and Related Biomarkers", Chatgilialoglu C, Ferreri C, Masi A,Melchiorre M, Sansone A, Terzidis M.A. and Torregiani A. Chimia 66, 368-371 (2012);

“ Inhibition of amyloid peptide fragment Aß25-35 fibrillogenesis and toxicity by N- terminal β-amino acid-containing esapeptides: is taurine moiety essential for in vivo effects?“ Cesare Giordano, Anna Sansone, Annalisa Masi, Alessandra Masci, Luciana Mosca, Roberta Chiaraluce, Alessandra Pasquo and Valerio Consalvi. Chemical Biology & Drug Design 79, 30-37 (2012);

“Detection of enzyme activity trought catalityc signal amplification using Au nanoparticles”.Renato Bonomi, Alessandro Cazzolaro, Anna Sansone, Paolo Scrimin,* and Leonard J. Prins*.Angew Chem Int Ed Engl. 2011 Mar 1;50(10):2307-12. Epub 2011 Jan 31

"Synthesis and activity of endomorphin-2 and morphiceptin analogues with proline surrogates in position 2".Cesare Giordano, Anna Sansone, Annalisa Masi, Gino Lucente, Pasqualina Punzi, Adriano Mollica, Francesco Pinnen, Federica Feliciani, Ivana Cacciatore, Peg Davis, Josephine Lai, Shou-Wu Ma, Frank Porreca and Victor Hruby . .Eur J Med Chem. 2010 Oct;45(10):4594-600.

X-ray structure and conformation of N-(terbutyloxycarbonyl)-L-methionyl-(1-aminocyclopent-3-ene-1-carbonyl)-L-phenylalanine methylester (Boc0-Met1-Cpg2-Phe3-OMe).Pasquale Mura, I, Mercedes Camalli, Gaetano Campi, Gino Lucente, Cesare Giordano, Adriano Mollica, Anna Sansone and Domenica Torino. Z. Kristallogr. 224 (2009) 225–228

"Indolylarylsulfones Bearing Natural and Unnatural Amino Acids. Discovery of Potent Inhibitorsof HIV-1 Non-Nucleoside Wild Type and Resistant Mutant Strains Reverse Transcriptase and Coxsackie B4 Virus". Francesco Piscitelli, Antonio Coluccia, Andrea Brancale,Giuseppe La Regina, Anna Sansone, Cesare Giordano,Jan Balzarini,Giovanni Maga, Samantha Zanoli, Alberta Samuele,Roberto Cirilli,Francesco La Torre, Antonio Lavecchia, Ettore Novellino,and Romano Silvestri. J Med Chem. 2009 Apr 9;52(7):1922-34.

"Synthesis and bioactivity of chemotactic tetrapeptides: fMLF-OMe analogues incorporating spacer aminoacids at the lateral positions". Gino Lucente, Cesare Giordano, Anna Sansone, Domenica Torino and Susanna Spisani Amino Acids (2009) Jul;37(2):285-95.

"Synthesis and activity of fibrillogenesis peptide inhibitors related to the 17-21 -amyloid sequence" Cesare Giordano, Annalisa Masi, Aldo Pizzini, Anna Sansone, Valerio Consalvi, Roberta Chiaraluce and Gino Lucente. Eur. journal Medicinal Chemistry (2009), 44, 179-189.

"Effect of intrarticular administration of glucosamine and a peptidyl-glucosamine derivative in a rabbit model of experimental osteoarthritis: a pilot study". Anna Scotto d'Abusco, Alessandro Corsi, Maria Grazia Grillo, Claudio Cicione, Valentina Calamia; Gianluca Panzini; Anna Sansone; Cesare Giordano; Laura Politi, Roberto Scandurra. Rheumatol Int.( 2008) Mar; 28(5):437-43.

"Chemotactic tripeptides incorporating at position 2 -aminoacid residues with unsaturated side chains" Gino Lucente, Mario Paglialunga Paradisi, Cesare Giordano, Anna Sansone, Domenica Torino, and Susanna Spisani". Amino Acids (2008) 35: 329-338.

“Synthesis, conformation and biogical activity of the centrally modified pseudopeptidic analogues of the For-Met-Leu-Phe-OMe”. C. Giordano, G. Lucente, A. Masi, M. Paglialunga Paradisi, A. Sansone, S. Spisani. Amino Acids (2007), 33(3) 477-48.

“α-Pepdide/β-sulfonamidopeptide hybrids: analogs of the chemotactic agent for-Met-Leu-Phe-OMe”. Cesare Giordano, Gino Lucente, Annalisa Masi, Mario Paglialunga Paradisi, Anna Sansone, Susanna Spisani. Bioorganic & Medicinal Chemistry 14 (2006).

“β-Peptido sulfonamides: For-Met-Leu-Phe-OMe analogues containing taurine and chiral β-amino-ethansulfonic acid residues.” Cesare Giordano, Marianna Nalli, Mario Paglialunga Paradisi, Anna Sansone, Gino Lucente, Susanna Spisani. Il Farmaco 59 (2004).

Other info: 

Publications in Books

A pharmacological approach to prevent fibrillogenesis (Cesare Giordano, Anna Sansone, Luciana Mosca, Alessandra Masci Alessandra Pasquo,Roberta Chiaraluce and Valerio Consalvi3Multidisciplinary Viewpoint on Neurodegenerative Diseases, 2012: 1-12 ISBN: 978-81-7895-557-5 Editors: Mario Di Carlo, P.L. San Biagio and D. Bulone

Scientific Contributions (Lecture and Posters)
Acidi grassi trans Polinsaturi:librerie molecolari poer la qualità di nutraceutica e cibi funzionali.Carla Ferreri, Anna Sansone, Chryssostomos Chatgilialoglu, Giorgia Giacometti, Roberta Scanferlato, Simone Deplano, Valentina Sunda, Itziar Tueros, Maxtalen Uriarte .Bologna 21 ottobre 2016.

Trans- liposomes: formation and potential for synergic anticancer strategies. G. Giacomertti, S Tortorella, A. Sansone,C. Chatglialoglu, C. Ferreri. Londra 20-22 dicembre 2015

Integrated analytical approach for fattya cid based-nutraceutical characterization". Anna Sansone, Giorgia Giacometti, Paolo Dambruoso,Simone Deplano, chrysostomos Chatglialoglu,Carla Ferreri. Bologna 25 settembre 2015

Lipidomic studies on lipoprotein:insights on the cis/trans C16:1 monounsaturated fatty acid content
Anna Sansone, Chryssostomos Chatgilialoglu, Carla Ferreri. Zadar September 11th - 12th, 2013

Synthesis of (5'R)-and (5'S)-5',8-cyclo-2-deoxyadenosines phosphoramidites: a free radical approach.(Anna Sansone Michael Terzidis and Chryssostomos Chatgilialoglu) ISOFR11 Bern, July-1-5 2012.

“New intracellular chemosensors based on peptide dendrons”. A. Sansone, L. Baù, F.Mancin, L. Prins , P. Scrimin .(Sisoc VIII, Padova 3-6 luglio 2010)[u].[/u]

“Beta-amyloid induces an enhancement of Parp activity in a cellular model of neurodegeneration.”L. Mosca, I. De Zottis, A. Sansone, C. Giordano, R. Chiaraluce, I. Tempera, A. Mai, M. d’Erme.(9th Int Conference AD/PD 2009 Prague Czech Republic March 11-15 2009).
“Indolylarylsulfones Bearing Natural and Unnatural Amino Acids are Potent HIV-1 Reverse Transcriptase and Coxsackie B4 Virus Non-Nucleoside Inhibitors.”F. Piscitelli, A. Coluccia, A. Brancale, G. La Regina, A. Sansone, C. Giordano, J Balzarini, G Maga, S. Zanoli, A. Samuele, R. Cirilli, F. La Torre, A. Lavecchia, E. Novellino, R. Silvestri. .(The 22nd International Meeting on Antiviral Research, Miami Beach, Florida, USA, May 3-7, 2009)

(S)-Aziridine-2-carboxylic acid. A constrained and reactive aminoacid unit for the synthesis of bioactive peptide analogues. Domenica Torino, Adriano Mollica, Anna Sansone and Gino Lucente. 3° Meething nuove prospettive in Chimica farmaceutica Castelvecchio Pascoli 13-14 febbraio 2009)
Bioactive oligopeptides. Synthesis, conformation and activity of chemotactic tripeptides incorporating unsaturated a-aminoacid residues at the central position. Anna Sansone, Domenica Torino, Cesare Giordano, Gino Lucente,, Adriano Mollica, Pasquale Mura, Mercedes Camalli, Gaetano Campi, Susanna Spisani.(3° Meething nuove prospettive in Chimica farmaceutica Castelvecchio Pascoli 13-14 febbraio 2009)

"Espansione del backbone del tripeptide chemotattico fMLF-OMe mediante introduzione di residui spaziatori nelle posizioni laterali." Domenica Torino Anna Sansone, Cesare Giordano, Gino Lucente e Susanna Spisani..(7° Sigma Aldrich Young Chemists Symposium: 7° S.A.Y.C.S. Riccione (Palazzo del Turismo), 22-24 Ottobre 2007)
"Introduzione di residui b-amminoacidi "Taurina b-Prolina" chimera in tetrapeptidi oppioidi". Anna Sansone, Domenica Torino, Cesare Giordano, Gino Lucente e Roberta Lattanzi.(7° Sigma Aldrich Young Chemists Symposium: 7° S.A.Y.C.S. Riccione (Palazzo del Turismo), 22-24 Ottobre 2007)

"Synthesis of Indolyl Aryl Sulfones bearing Natural and Unnatural Aminoacids as Potent HIV-1 Non-Nucleoside reverse transcriptase"Antonio Lavecchia, Ettore Novellino and Romano Silvestri.Francesco Piscitelli, Giuseppe La Regina, Antonio Coluccia, Anna Sansone, Cesare Giordano, Alberto Bergamini, Anna Sinistro, Antonella Cavazza, Giovanni Maga, Alberta Samuele, Samantha Zanoli, Antonio Lavecchia, Ettore Novellino and Romano Silvestri.(XVIII Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana chieti 16-20 settembre 2007).

"Synthesis and activity of chemotactic peptides. Analogues of fMLF-OMe modified at the N-terminal Met residue". [u]Adriano Mollica, Domenica Torino, Anna Sansone, Mario Paglialunga Paradisi, Francesco Pinnen, , Susanna Spisani and Gino[/u] Lucente.(XVIII[u] Convegno Nazionale della Divisione di Chimica Farmaceutica della Società Chimica Italiana chieti 16-20 settembre 2007).[/u]

"Synthesis and activity of fibrillogenesis peptide inhibitors related to the17-21 b-amyloid1-40 sequence". Anna Sansone.(European school of medicinal chemistry: 27° advanced course of Medicinal Chemistry and ‘E. Duranti’ National Seminar for PhD Student. Urbino 1-6 luglio 2007)

"B-Peptido sulfonamides.Analogues of bio-active peptides containing taurine and chiral b-aminoethansulfonic acid residues". C. Giordano, M. Nalli, M. Paglialunga Paradisi, A. Sansone, A. Masi,G. Lucente.(Conferenza sulla ricerca Scientifica ‘Dalle molecole agli organismi’ Roma, 9-10 dicembre 2004)